C-terminal truncated hepatitis B virus X protein regulates tumourigenicity, self-renewal, and chemoresistance via STAT3/Nanog signalling pathway: abridged secondary publication
RHH Ching, KMF Sze, EYT Lau, YT Chiu, JMF Lee, IOL Ng, TKW Lee
Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong: State Key Laboratory for Liver Research & Department of Pathology
1. HBx-ΔC1 (a major C-terminal truncated form reported with a breakpoint at 130aa) regulates cancer stem cell properties including tumour initiation, self-renewal, drug resistance, and invasiveness.
2. HBx-ΔC1 regulates liver cancer stem cells through Stat3/Nanog cascade, which provides a new insight for the therapeutic intervention for hepatitis B virus–related hepatocellular carcinoma.