Genetic prediction models for primary open-angle glaucoma: translational research
LJ Chen, CP Pang, CCY Tham, CKS Leung
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong
1. This study investigated the association of 48 genetic markers in multiple genes with primary open-angle glaucoma (POAG).
2. This study confirmed the association of variant rs4236601 in the CAV1/CAV2 gene locus with POAG in Chinese, and suggested a common variant in this locus, rs3801994, as a new genetic biomarker for POAG in Chinese.
3. This study revealed the association of the CDNK2B gene variant rs3217986 with normal-tension POAG, and rs2157719 with high-tension POAG in Chinese.
4. This study confirmed the association of variant rs33912345 in the SIX6 gene with POAG, and identified a new variant rs12436579 for the disease in Chinese.
5. This study simulated a genetic prediction model that can incorporate multiple gene variants for the prediction of individual risk of POAG.