Topically applied adipose-derived mesenchymal stem cell treatment in experimental focal cerebral ischaemia
GKC Wong1,2, PK Lam1,2, AWI Lo3, AKY Chan3, YX Wang4, WS Poon1,2
1 Department of Surgery, The Chinese University of Hong Kong
2 Chow Tai Fook-Cheng Yu Tung Surgical Stem Cell Research Center, The Chinese University of Hong Kong
3 Department of Anatomical Pathology, Queen Mary Hospital
4 Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong
1. Topically applied mesenchymal stem cells plus fibrin sealant can home to ischaemic penumbra, reduce cerebral infarction volume, and improve the neurological function from cerebral ischaemia in a rodent middle carotid artery occlusion model mimicking severe stroke secondary to a major cerebral artery occlusion.
2. Topical mesenchymal stem cell plus fibrin sealant treatment is promising and should be optimised for safety and efficacy.