Indirubin-3′-oxime as an antiviral and immunomodulatory
agent in treatment of severe human influenza virus infection
MCW Chan1, RWY Chan1, CKP
Mok1,2, NK Mak3, RNS Wong3
1 Centre of Influenza Research, School
of Public Health, LKS Faculty of Medicine, The University of Hong Kong
2 The HKU-Pasteur Research Pole, School
of Public Health, LKS Faculty of Medicine, The University of Hong Kong
3 Department of Biology, Faculty of
Science, Hong Kong Baptist University
1. Two indirubin derivatives (indirubin-3′-oxime
and E804) demonstrate strong antiviral and immunomodulatory effects on
human macrophages and type-I alveolar epithelial cells after influenza
H5N1 virus infection.
2. In mice infected with H5N1 virus, the use of E804 does not improve survival or weight loss but significantly reduces cytokine and chemokine expression and secretion, compared with controls.
3. Cyclin-dependent kinases pathway is involved in the antiviral and immunomodulatory effects of indirubin upon influenza H5N1 virus infection.
2. In mice infected with H5N1 virus, the use of E804 does not improve survival or weight loss but significantly reduces cytokine and chemokine expression and secretion, compared with controls.
3. Cyclin-dependent kinases pathway is involved in the antiviral and immunomodulatory effects of indirubin upon influenza H5N1 virus infection.