Early neurodegenerative biomarkers and clinical outcome
in psychiatric patients with rapid eye movement sleep behaviour disorder:
a prospective study
YK Wing1, SP Lam1, VCT Mok2,
J Zhang1, JMY Tsoh3,4, EYL Leung5
1 Department of Psychiatry, The Chinese
University of Hong Kong
2 Department of Medicine and
Therapeutics, The Chinese University of Hong Kong
3 Department of Psychiatry, Prince of
Wales Hospital
4 Department of Psychiatry, Shatin
Hospital
5 Department of Nuclear Medicine and
Positron Emission Tomography, Hong Kong Sanatorium and Hospital
1. Patients who have rapid eye movement sleep
behaviour disorder (RBD) as well as psychiatric illness (pRBD) may have a
neurodegenerative outcome. The annual incidence of RBD was 1.9% in
psychiatric patients. The incidence of Parkinson’s disease in pRBD
patients was 1.1%.
2. In most patients, RBD runs a persistent course. Despite symptomatic drug treatment, RBD symptoms and consequent sleep-related injury are still common.
3. Compared with psychiatric patients without comorbid RBD, pRBD patients have more prominent symptoms of depression and anxiety.
4. Persistent olfactory dysfunction is a feature in pRBD.
2. In most patients, RBD runs a persistent course. Despite symptomatic drug treatment, RBD symptoms and consequent sleep-related injury are still common.
3. Compared with psychiatric patients without comorbid RBD, pRBD patients have more prominent symptoms of depression and anxiety.
4. Persistent olfactory dysfunction is a feature in pRBD.