Early neurodegenerative biomarkers and clinical outcome in psychiatric patients with rapid eye movement sleep behaviour disorder: a prospective study
YK Wing1, SP Lam1, VCT Mok2, J Zhang1, JMY Tsoh3,4, EYL Leung5
1 Department of Psychiatry, The Chinese University of Hong Kong
2 Department of Medicine and Therapeutics, The Chinese University of Hong Kong
3 Department of Psychiatry, Prince of Wales Hospital
4 Department of Psychiatry, Shatin Hospital
5 Department of Nuclear Medicine and Positron Emission Tomography, Hong Kong Sanatorium and Hospital
1. Patients who have rapid eye movement sleep behaviour disorder (RBD) as well as psychiatric illness (pRBD) may have a neurodegenerative outcome. The annual incidence of RBD was 1.9% in psychiatric patients. The incidence of Parkinson’s disease in pRBD patients was 1.1%.
2. In most patients, RBD runs a persistent course. Despite symptomatic drug treatment, RBD symptoms and consequent sleep-related injury are still common.
3. Compared with psychiatric patients without comorbid RBD, pRBD patients have more prominent symptoms of depression and anxiety.
4. Persistent olfactory dysfunction is a feature in pRBD.