Ictal intracranial electroencephalography using wavelet analysis of high-frequency oscillations in Chinese patients with refractory epilepsy
HW Leung1, WS Poon2, PKL Kwan3, CHT Lui4, TL Poon5, ELY Chan6, SC Yuen7
1 Department of Medicine and Therapeutics, The Chinese University of Hong Kong
2 Department of Surgery, The Chinese University of Hong Kong
3 Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia
4 Department of Medicine, Tseung Kwan O Hospital
5 Department of Neurosurgery, Queen Elizabeth Hospital
6 Department of Medicine and Geriatrics, Tuen Mun Hospital
7 Department of Neurosurgery, Tuen Mun Hospital
1. Both intracranial electroencephalography and detection of wavelet-transformed high-frequency oscillations (HFOs) may be beneficial in surgery for patients with focal epilepsy.
2. Detection of wavelet-transformed HFOs may increase the percentage of patients eligible for resective surgery by 5% to 6.5%, compared with intracranial electroencephalography alone.
3. Detection of wavelet HFOs may improve surgical outcome by 17% to 18%, compared with intracranial electroencephalography alone, and by 30% if no intracranial electroencephalography is used.
4. High-frequency oscillations that are detected at the onset of seizure help determine seizure outcome.
5. Cortical areas that demonstrate hyperexcitability may be associated with HFOs.