Epstein-Barr virus–driven promoter hypermethylated genes in gastric cancer
J Yu, KF To, QY Liang
Institute of Digestive Disease, Department of Medicine and Therapeutics, The Chinese University of Hong Kong
1. Somatostatin receptor 1 (SSTR1), meiotic recombination protein 8 (REC8), and interleukin 15 receptor, alpha (IL15RA) were identified as novel Epstein-Barr virus (EBV)–driven promoter hypermethylated genes in EBV-positive AGS-EBV, compared with EBV-negative AGS.
2. Transcriptional silence of SSTR1 and REC8 in EBV-associated gastric cancers is mediated by promoter methylation. This association was not observed for IL15RA.
3. Gain- and loss-of-function experiments revealed that SSTR1 and REC8 acted as tumour suppressors through modulating cell proliferation, cell cycling, apoptosis, and migration.