Hong Kong Med J 2016 Jun;22(3):270–8 | Epub 22 Apr 2016
DOI: 10.12809/hkmj154678
© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
 
REVIEW ARTICLE
Magnetic resonance imaging of the fetal brain
Lawrence MF Tee, FHKCR, FHKAM (Radiology)1; Elaine YL Kan, FHKCR, FHKAM (Radiology)1; Joey CY Cheung, MHlthSc (MRS)1; WC Leung, MD, FRCOG2
1 Department of Diagnostic and Interventional Radiology, Kwong Wah Hospital, Yaumatei, Hong Kong
2 Department of Obstetrics and Gynaecology, Kwong Wah Hospital, Yaumatei, Hong Kong
 
Corresponding author: Dr Lawrence MF Tee (lmftee@gmail.com)
 
 Full paper in PDF
Abstract
Introduction: This review covers the recent literature on fetal brain magnetic resonance imaging, with emphasis on techniques, advances, common indications, and safety.
 
Methods: We conducted a search of MEDLINE for articles published after 2010. The search terms used were “(fetal OR foetal OR fetus OR foetus) AND (MR OR MRI OR [magnetic resonance]) AND (brain OR cerebral)”. Consensus statements from major authorities were also included. As a result, 44 relevant articles were included and formed the basis of this review.
 
Results: One major challenge is fetal motion that is largely overcome by ultra-fast sequences. Currently, single-shot fast spin-echo T2-weighted imaging remains the mainstay for motion resistance and anatomical delineation. Recently, a snap-shot inversion recovery sequence has enabled robust T1-weighted images to be obtained, which is previously a challenge for standard gradient-echo acquisitions. Fetal diffusion-weighted imaging, diffusion tensor imaging, and magnetic resonance spectroscopy are also being developed. With multiplanar capabilities, superior contrast resolution and field of view, magnetic resonance imaging does not have the limitations of sonography, and can provide additional important information. Common indications include ventriculomegaly, callosum and posterior fossa abnormalities, and twin complications. There are safety concerns about magnetic resonance–induced heating and acoustic damage but current literature showed no conclusive evidence of deleterious fetal effects. The American College of Radiology guideline states that pregnant patients can be accepted to undergo magnetic resonance imaging at any stage of pregnancy if risk-benefit ratio to patients warrants that the study be performed.
 
Conclusions: Magnetic resonance imaging of the fetal brain is a safe and powerful adjunct to sonography in prenatal diagnosis. It can provide additional information that aids clinical management, prognostication, and counselling.
 
 
 
Introduction
Fetal magnetic resonance (MR) imaging has been an invaluable adjunct to sonography in evaluation of the fetal brain since its introduction in the 1980s. In recent years, there has been an exponential growth in its clinical use, facilitated by technological advancements such as ultra-fast imaging sequences, diffusion-weighted imaging (DWI), and parallel imaging techniques. To date, sonography remains the mainstay modality in prenatal evaluation, owing to its low cost, abundant availability, and well-established literature support. Nonetheless, MR imaging has been shown to provide useful complementary information to sonography,1 2 and has a number of advantages over sonography, including superior contrast resolution, increased field of view (FOV), and the ability to image unhampered by an ossified calvarium, large maternal body habitus, or oligohydramnios.3 4 5 Currently, fetal MR imaging is most commonly used to confirm or characterise an abnormality that is suspected on sonography, or to screen fetuses at increased risk of neurodevelopmental disabilities.
 
In this article, we review the recent literature and developments in MR imaging of the fetal brain, with an emphasis on the safety, imaging techniques and protocols, and common clinical indications.
 
Methods
We performed a MEDLINE search for all the relevant scientific articles published in 2010 or later, using the keywords “(fetal OR foetal OR fetus OR foetus) AND (MR OR MRI OR [magnetic resonance]) AND (brain OR cerebral)”. All papers published in English and on human subjects were included. This yielded a total of 331 articles. These were then evaluated for their content and relevance to this review article, with case reports being excluded. Ultimately, 40 articles were deemed relevant and used as the literature basis of this review. In addition, four consensus statements and clinical guidelines from major authorities, including the American College of Radiology (ACR), the International Commission on Non-Ionizing Radiation Protection (ICNIRP), the Health and Safety Executive (HSE), and the American Academy of Pediatrics, were included. Relevant or important citations in the articles were also reviewed. With reference to the data from these articles, we describe the imaging techniques and recent developments, common clinical indications, and safety issues of MR imaging of the fetal brain.
 
Safety
Fetal imaging is a relatively new MR application. While it is generally believed to be a safe and noninvasive procedure,6 safety concerns have been raised regarding the possible or theoretical adverse effects related to the radiofrequency (RF) field and acoustic exposure.7 A number of animal studies have been performed to assess the safety of MR imaging in pregnant animals and animal fetuses, but there is a lack of consensus regarding the actual risks, if any.7 In addition, these studies were performed under various conditions and MR protocols, making it difficult to directly extrapolate the results to human fetal MR examination. Overall, most studies have shown no deleterious effects of MR imaging on the developing fetus.4 7 8 9
 
Radiofrequency-induced hyperthermia
Radiofrequency-induced hyperthermia is a potential hazard in MR imaging. During an MR examination, RF energy is converted to heat via Faraday’s law and is normally dissipated by blood flow. The amount of heat generated is a function of magnetic field strength, RF field, body size, tissue resistance, and scan time. Generally, pregnant women have a similar ability to maintain heat balance to non-pregnant women in a warm environment. Since the fetus does not possess the effective heat dissipation mechanisms of an adult, fetal temperature is dissipated via amniotic fluid and umbilical blood flow to the mother, and is thus coupled to maternal temperature, which is usually 0.5°C higher. Therefore, the fetus is considered to be more sensitive to hyperthermia. The 2004 ICNIRP report concludes that “Excessive heating is a potential teratogen; because of uncertainties in the RF dosimetry during pregnancy, it is recommended that exposure duration should be reduced to the minimum and that only the normal operation level is used”, and that “It seems reasonable to assume that adverse developmental effects will be avoided with a margin of safety if the body temperature of pregnant women does not rise by more than 0.5°C and the temperature of the fetus is less than 38°C”.10
 
Acoustic exposure
A characteristic of the switching gradient fields is the production of acoustic noise. When the alternating low-frequency currents flow through the gradient coils, which are immersed in the high static magnetic field B0, forces are exerted on the gradient coils that move like a loudspeaker coil and generate sound waves. Exposure to excessive loud noises can result in a reduced sensitivity of the hair cells in the organ of Corti and cause a temporary shift in the threshold of hearing. The impact depends on the sound pressure level (measured in A-weighted decibel, dB[A]) and duration of exposure. A sufficient injurious acoustic exposure can result in a permanent hearing loss; 85 dB(A) is the threshold for permanent hearing loss following long-term exposure. Thus, the ICNIRP recommends that hearing protection should be provided to patients when sound levels exceed 80 dB(A).10 It is unclear how these guidelines can be applied to the fetus, in whom the cochlea is developing, and the external auditory canal and middle ear cavity are fluid-filled instead of air-filled. Therefore, concerns have been raised regarding possible effects of acoustic exposure during fetal MR on the developing auditory system of the fetus, especially in echo-planar imaging that is the loudest sequence in current clinical use.
 
In the literature reviews published by HSE and American Academy of Pediatrics, most published studies were limited by their methodology and study design, and no conclusive evidence of acoustic damage was shown.11 12 A 3-year follow-up study of children who underwent fetal MR imaging showed no adverse long-term effect on hearing, although this was limited by the relatively small sample size.7 Compared with adult patients, the exact effect of acoustic noise on the fetus is difficult to ascertain, because there are a number of variables that could alter the effect, for instance, maternal body size, volume of amniotic fluid, MR sequences used, and duration of scanning. In a study by Glover et al,13 the authors aimed to simulate the in-utero acoustic environment by inserting a microphone into the fluid-filled stomach of a volunteer, and found a >30 dB attenuation in sound intensity. This provides some reassurance that a level close to the instantaneous damage threshold (120 dB[A]) could be reduced to an acceptable level (<90 dB[A]). Overall, the data from the current literature provide reassuring clinical and experimental evidence that suggests no significant risk of acoustic injury to the fetus during prenatal MR imaging.
 
Gadolinium contrast medium
Gadolinium is a pregnancy class C drug, and currently there are no documented indications for use of gadolinium contrast in fetal MR imaging.9 Gadolinium can pass through the placental barrier and enter the fetal circulation, with unknown and potentially harmful effects on the fetus. In animal studies, large doses of MR imaging gadolinium-based contrast agents have been shown to be associated with intrauterine death and congenital anomalies.7 The 2013 ACR guidance document on MR safe practices states that “MR contrast agents should not be routinely provided to pregnant patients”.14
 
Summary
The 2013 ACR guidance document on MR safe practices states that “Pregnant patients can be accepted to undergo MR scans at any stage of pregnancy if, in the determination of a level 2 MR personnel-designated attending radiologist, the risk-benefit ratio to the patient warrants that the study be performed”.14 While present data have not conclusively documented any deleterious effects of MR imaging exposure on the developing fetus, as a precaution, it is generally recommended to wait until the second trimester onwards before performing fetal MR imaging. This has the additional benefit of minimising the technical challenges due to the small size and excessive motion of younger fetuses.
 
Techniques and protocols
Coil selection
Fetal MR imaging is typically performed on a 1.5-tesla magnet. Currently, either multi-channel phased-array coils or cardiac surface coils are employed for fetal brain MR, with the coils placed directly over the fetal head.6 These coils generally lack mechanical design and flexibility, as maternal size is highly variable and is also dependent on the gestational age of the fetus. With the advent of parallel imaging techniques, the numbers of elements in phased-array coils have continuously increased to achieve a higher signal-to-noise ratio (SNR) and shorter scan times. More recently, the invention of the digital coil platform combined with multiple coil elements has further enhanced SNR beyond the capabilities of the adult eight-channel torso coil routinely used in fetal imaging.
 
Patient positioning
Patients are placed in a semi-decubitus position, rotating about 45° to the left side to avoid compression of the inferior vena cava and supported with foam pads to maximise comfort so as to minimise maternal and fetal movement. No maternal or fetal sedation is required.
 
Scout views
Scout images are obtained to localise the fetus and also serve as a general survey of the feto-placental unit. An initial localiser is obtained in three orthogonal planes with respect to the mother, using 6- to 8-mm thick slices with a 1- to 2-mm gap and a large FOV. The localiser is used to visualise the position of the fetus and determine fetal sidedness, as well as to ensure that the coil is centred over the fetal brain. At our centre, we use a gradient-echo scout localiser with a large FOV of 450 mm to cover the abdomen and pelvis of the mother, with a resolution of 1.76 x 1.76 x 10 mm3, and 20 slices in three orthogonal planes. A repeat localiser is then placed in the three orthogonal planes of the fetal brain. During the examination, each sequence also serves as a scout for the next. Due to fetal movement throughout the scanning process, repeating of scout localisers and repositioning of the coil are sometimes necessary. Therefore efforts should be made to keep the scanning time short.
 
Sequences
High image quality and resolution are crucial to accurate diagnosis; at the same time, a relatively short scan time is required to minimise the effects of fetal movement. Therefore, the choice of technical parameters should strike a balance between image quality and scan time (Table).
 

Table. Typical sequence parameters for fetal brain MR imaging at our centre (Achieva XR 1.5T; Philips Medical Systems, Best, Netherlands)
 
Single-shot fast spin-echo (SSFSE) T2-weighted imaging is regarded as the mainstay of fetal MRI.3 5 6 8 9 15 16 17 18 19 It provides excellent delineation of cerebral anatomy and requires a total acquisition time of <1 second per image. On our 1.5T MR scanner system (Achieva XR 1.5T; Philips Medical Systems, Best, Netherlands), SSFSE T2-weighted sequences in the axial, coronal, and sagittal plane of the fetal brain are acquired, with 25 slices in 35 seconds, resolution at 0.79 x 0.79 x 3.2 mm, 0.3 mm gap, long echo train length (ETL) of 227 and relatively short repetition time (TR) of 1450 ms, and use of the driven equilibrium pulse to enhance T2 contrast with a shorter TR.
 
Single-shot multiplanar T1-weighted turbo field-echo sequences are acquired to detect haemorrhage, fat, or calcification.3 5 6 8 9 Snap-shot inversion recovery, a dedicated optimised inversion-recovery-prepared SSFSE T1-weighted sequence, offers detailed delineation of normal fetal brain anatomy and myelination near term.20 At our centre, we use an inversion time of about 400 ms, resolution at 0.8 x 0.8 x 4 mm, 25 slices in 3 minutes 20 seconds, and single-shot mode with ETL of 230.
 
Diffusion-weighted imaging provides quantitative information about water motion and tissue microstructure, and can be used to identify focal areas of injury and delineate subtle anatomical structures and maturational changes.3 8 15 21 22 Other advanced techniques are also being developed and may provide functional and physiological information, including fetal MR spectroscopy, diffusion tensor imaging, and functional imaging,7 8 23 24 25 26 27 28 29 30 although their development is still at an early stage.
 
Indications
Fetal MR imaging is often performed to further evaluate a suspected abnormality detected on sonography. By providing additional information on the suspected abnormality and detecting associated cerebral abnormalities that are otherwise occult on sonography, fetal MR imaging can guide antenatal and perinatal management, as well as assist in the counselling of current and future pregnancies.5 31 32 33 34 It has also been shown to demonstrate a high diagnostic accuracy when compared with repeat or postnatal MR imaging.35 36 The most common clinical indications for fetal MR imaging will be discussed below.
 
Ventriculomegaly
Ventriculomegaly is one of the most common clinical indications for fetal MR imaging, mainly to detect other associated abnormalities that are occult on sonography. Ventriculomegaly is defined as atrial width of >10 mm on sonography, measured in the axial plane, at the level of the frontal horns and cavum septi pellucidi, at the level of the glomus of the choroid plexus, and perpendicular to the long axis of the lateral ventricle.3 5 6
 
Ventriculomegaly is a relatively common abnormality detected on prenatal sonography. It is a heterogeneous disease with various aetiologies that can be classified into developmental, destructive, and obstructive pathologies. An important prognostic factor is whether the ventriculomegaly is isolated, or with additional associated abnormalities.26 Studies have shown that up to 80% of fetuses with ventriculomegaly have other associated central nervous system (CNS) abnormalities, and is associated with poor postnatal neurological and developmental outcomes3 37 (Fig 1). These include agenesis of the corpus callosum, cortical malformation, periventricular nodular heterotopia, and destructive processes such as periventricular leukomalacia, porencephaly, and intra-ventricular and subependymal haemorrhage.3 6 37 On the other hand, the majority of fetuses with isolated mild ventriculomegaly show normal neurodevelopmental outcomes. Fetal MR imaging has been shown to have a high sensitivity and specificity for these brain abnormalities18 that may be occult and unidentified on sonography.25 34 38 39 40 These data highlight the role of fetal MR imaging in the prognostication of ventriculomegaly, and have significant implications on parental counselling and perinatal management.
 

Figure 1. A fetus with a history of borderline ventriculomegaly and suspected partial agenesis of corpus callosum on antenatal ultrasound at 35 gestational weeks
(a) An axial T2 image performed at 35 gestational weeks showing mild ventriculomegaly. There is no evidence of agenesis of corpus callosum. Neonatal magnetic resonance imaging performed at 1 month of age: (b) T1 inversion recovery sequence showing persistent mild ventriculomegaly with prominence of choroid plexuses (arrows), and (c) T1-weighted sequence with gadolinium revealing diffuse enhancement of the choroid plexuses (arrows); overall findings suggest diffuse villous hyperplasia of choroid plexus
 
Corpus callosum abnormalities
The corpus callosum is the main commissural pathway in the brain and comprises the rostrum, genu, body, and splenium. Beginning at 8 weeks of gestation, it develops from the lamina of His, with an apparent anteroposterior progression, starting from the genu, progressing posteriorly to the body and splenium, followed by the rostrum. By 15 to 20 weeks, the corpus callosum has assumed its final shape with fusion of all of its parts.6 Thus caution should be exercised when evaluating the corpus callosum before 20 weeks.
 
Abnormalities of the corpus callosum include agenesis, hypogenesis, dysgenesis, hypoplasia, and destruction. The precise incidence of corpus callosum abnormalities is difficult to ascertain because of selection bias in reported series. In a large population-based study looking at data from the California Birth Defect Monitoring Program,41 the authors identified 630 (0.019%) cases of agenesis or hypoplasia of the corpus callosum in 3.4 million live births. While agenesis of the corpus callosum can sometimes be seen in asymptomatic individuals, most patients exhibit variable neurological symptoms, including developmental delay, cognitive impairment, and epilepsy. There is also a high association with other CNS abnormalities such as sulcation abnormalities, Dandy-Walker malformation, Chiari II malformation, and grey matter heterotopia.3 6 9
 
On sonography, the corpus callosum is best visualised and evaluated on the mid-sagittal image, but obtaining an optimal mid-sagittal view can be challenging, especially at an advanced gestational age. We often rely on indirect signs including absence of cavum septum pellucidum, colpocephaly, high-riding third ventricle, and radiating gyri.3 6
 
Fetal MR imaging overcomes these challenges with its multiplanar capabilities and is able to demonstrate the corpus callosum in its entire length on the mid-sagittal image as a curvilinear C-shaped T2 hypointense structure at the superior margin of the cavum septum pellucidum and lateral ventricles.3 The indirect signs of callosal agenesis, similar to those on sonography, can also be depicted on the axial and coronal images3 6 (Fig 2). Studies have shown a higher sensitivity and specificity with fetal MR imaging compared with sonography.38 42
 

Figure 2. A fetus of 35 gestational weeks
(a) Midline sagittal T2, (b) coronal T2, and (c) axial T2 images demonstrating agenesis of corpus callosum, as evidenced by radiating gyri (arrow), absence of cavum septum pellucidum (asterisk), colpocephaly and high-riding third ventricle (arrowhead)
 
The prognosis of corpus callosum abnormalities is highly variable, depending not on the callosal abnormality itself, but largely on the associated abnormalities in the CNS and other systems, and have been found to be as common as 85% on autopsy.5 Fetal MR imaging has been shown to demonstrate additional but sonographically occult anomalies in up to 93% of cases of callosal abnormalities.5 9 Accurate detection of associated abnormalities has an important implication on the prognostication of the current pregnancy and the recurrence risk in future pregnancies.3 5
 
Complications of monochorionic twin pregnancies
While fetal MR imaging is commonly used for further evaluation of suspected sonographic abnormalities, there has been an increasing clinical use in the screening of high-risk cases.3 31 43 Fetal MR imaging is particularly useful in monochorionic twin pregnancies complicated by twin-twin transfusion syndrome or co-twin fetal demise where sonography of the brain is unrevealing.43 44
 
In twin-twin transfusion syndrome, there is imbalanced blood flow from the smaller donor twin to the larger recipient twin via abnormal intertwin vascular connections in the shared common monochorionic placenta. The donor twin develops oliguria and oligohydramnios from volume depletion, while the recipient twin develops polyuria and polyhydramnios from volume overload. High morbidity and mortality are observed, with both donor and recipient twins at a higher risk of cerebral ischaemia and haemorrhage, and neurodevelopmental and sonographic abnormalities.3 44 Although imaging the oligohydramniotic twin is usually straightforward, imaging the polyhydramniotic twin can be difficult owing to excessive fetal motion.
 
In co-twin fetal demise, an increased risk of neurological impairment is seen in the surviving co-twin (Fig 3). The likely mechanisms of cerebral injury are believed to involve an acute haemodynamic disturbance due to exsanguination of the surviving co-twin into the dead fetus just before or at the time of fetal demise, as well as thromboembolic events at the time of demise.3 43
 

Figure 3. A 23-week gestation fetus with co-twin demise
(a) Sagittal T2, (b) coronal T2, and (c) axial T2 images showing small demised twin (arrows) and surviving twin with normal intracranial appearance
 
Because of the high morbidity in these twin pregnancy complications, fetal MR imaging can be employed to look for cerebral injuries even when sonography appears normal, such as periventricular leukomalacia, encephalomalacia, germinal matrix haemorrhage, intra-ventricular haemorrhage, intraparenchymal haemorrhage, and cortical malformations. It has been found that one third of the surviving twins of co-twin fetal demise had abnormal cerebral findings on fetal MR imaging; most of which were occult sonographically.41 In addition, early manifestations of cerebral ischaemia were better diagnosed with MR imaging than sonography, especially DWI.3 43
 
Posterior cranial fossa abnormalities
Fetal MR imaging is useful in evaluating the posterior cranial fossa, utilising its ability to directly visualise the cerebellar hemisphere, vermis, and brainstem in three orthogonal planes, providing global assessment of the posterior fossa structures with morphologic and biometric analysis. It is also used to evaluate for supratentorial abnormalities that are commonly associated with various posterior fossa diseases, and can aid diagnosis and prognostication. Posterior fossa abnormalities that can be evaluated by fetal MR imaging include Dandy-Walker spectrum, cerebellar hypoplasia, cerebellar dysplasia, cerebellar haemorrhage, and Chiari malformation.5 6 9 45
 
Dandy-Walker malformation is characterised by agenesis or hypoplasia of the cerebellar vermis, in association with an enlarged posterior fossa, torcular-lambdoid inversion, and cystic dilatation of the fourth ventricle.5 6 9 While severe cases of Dandy-Walker malformation can be readily identified by sonography, distinguishing milder forms of vermian hypoplasia from a mega cisterna magna or an arachnoid cyst can be challenging (Figs 4 and 5). This is even more difficult in the third trimester where ossification of the skull can limit sonographic assessment of the posterior fossa structures. With its multiplanar capabilities, fetal MR imaging can better evaluate the morphology of the vermis, as well as the anatomical relationship between a retrocerebellar cyst and the fourth ventricle, which can help differentiate a Dandy-Walker variant from other entities such as a mega cisterna magna.5 25 In addition, fetal MR imaging is able to evaluate the supratentorial structures, because the Dandy-Walker spectrum is also associated with supratentorial abnormalities such as agenesis of corpus callosum, polymicrogyria, neuronal heterotopia, and occipital encephalocele,5 and is associated with a poorer clinical outcome. On the other hand, radiologists should also be aware of the limitations of fetal MR imaging. At younger gestational age (such as <20 weeks), fetal MR imaging may have a reduced specificity, particularly in the diagnosis of isolated inferior vermian hypoplasia.5 9 This may be related to small size, fetal motion, volume averaging, and difficulty in obtaining a true mid-sagittal image. Follow-up MR imaging, either at a later gestational age or postnatally, is recommended in such cases.46
 

Figure 4. A 23-week gestation fetus with a history of enlarged retrocerebellar space on ultrasound
(a) Sagittal midline T2, (b) coronal T2, and (c) axial T2 images confirm that although the transverse diameter of the cerebellum is marginally small for gestational age, the cerebellar vermis (asterisks) was intact
 

Figure 5. A 32-week gestation fetus: antenatal ultrasonography showing enlarged retrocerebellar space
(a) Sagittal T2 images at midline, (b) coronal T2 image, and (c) sagittal T2 image depicting an intact cerebellar vermis (asterisk) and a mega cisterna magna (arrow)
 
The cerebellar hemispheres can be evaluated on fetal MR imaging by assessing their size and morphology in multiple planes, in which normative data have been published for different gestational ages.3 Furthermore, DWI can provide quantitative information on the developing cerebellum that normally demonstrates a progressive decline in diffusivity and apparent diffusion coefficient values with increasing gestational age.
 
Fetal MR imaging is also helpful in evaluating echogenic posterior fossa masses. Haemorrhage is typically hyperintense on T1-weighted images, hypointense on T2-weighted images, with susceptibility artefact on gradient echo T2* images, although the signal intensity can vary depending on the age of the haemorrhage. In addition to confirming the diagnosis, fetal MR imaging can also better delineate the location of the haemorrhage, whether it is intra-axial or extra-axial which have different pathophysiology. The underlying causes of the cerebellar haemorrhage can be evaluated on MR imaging, such as germinal matrix haemorrhages, vascular malformations, and congenital infections.38
 
Conclusions
Magnetic resonance imaging is a safe and powerful adjunct to sonography in prenatal evaluation of the fetal brain. Facilitated by recent technological advancements, fetal MR imaging is being increasingly used in the clinical evaluation of cerebral abnormalities and screening of high-risk fetuses. It can provide additional useful information that can alter clinical management and aid in prognostication and counselling. Radiologists and clinicians involved in prenatal imaging and management should be aware of the application and limitations of the modalities available in fetal imaging, so as to optimise the multidisciplinary care for our patients.
 
Acknowledgement
The authors thank Professor Mary Rutherford, Centre for the Developing Brain, Perinatal Imaging & Health Imaging Sciences & Biomedical Engineering Division, King’s College London, St Thomas’ Hospital, London, United Kingdom.
 
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