Hong Kong Med J 2016;22(Suppl 4):S43-7
Gender disparity of hepatocellular carcinoma: role of hepatitis B virus X protein and androgen receptor
YT Chiu, IOL Ng
Department of Pathology, The University of Hong Kong
1. The natural COOH-terminal truncated HBx
was more frequently detected in hepatocellular
carcinoma (HCC) in male than female patients.
2. There was no significant clinicopathological correlation with the HBx status or remarkable changes in androgen receptor (AR) expression in the presence of different truncated HBx mutants compared with full-length HBx.
3. Lower expression of AR was associated with more aggressive tumour phenotype and a higher metastatic potential of HCC.
2. There was no significant clinicopathological correlation with the HBx status or remarkable changes in androgen receptor (AR) expression in the presence of different truncated HBx mutants compared with full-length HBx.
3. Lower expression of AR was associated with more aggressive tumour phenotype and a higher metastatic potential of HCC.