Hong Kong Med J 2016;22(Suppl 4):S37-42
Functional characterisation of hepatitis B viral X protein/microRNA-21 interaction in HBV-associated hepatocellular carcinoma
CH Li, SC Chow, DL Yin, TB Ng, YC Chen
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong
1. miR-21 overexpression is critical to promote early carcinogenesis of hepatocytes upon hepatitis B virus infection.
2. HBx-induced IL-6-STAT3 pathway upregulates miR-21 expression.
3. The high dependency of miR-21 expression on HBx is a unique viral oncogenic pathway aberrantly affecting gene expression network.
4. Inhibition of miR-21 attenuates the anchorage-independent colony formation and subcutaneous tumour growth of non-tumour hepatocytes.