Hong Kong Med J 2016;22(Suppl 4):S16-21
Oral feeding of minocycline attenuates glial activation and reductions of tau and drebrin in response to systemically injected cytokines
DCH Poon, YS Ho, CF Lau, K Chiu, RCC Chang
Laboratory of Neurodegenerative Diseases, School of Biomedical Sciences, The University of Hong Kong
1. The use of minocycline to regulate the neuropathological effects of systemically administered cytokines was studied.
2. Systemic cytokines cause glial activation, and reduce tau and drebrin in the hippocampus. Minocycline reverses these effects of cytokines, suggesting that it may be neuroprotective against cytokine storm.