Hong Kong Med J 2016;22(Suppl 4):S10-2
Definition of the cellular interactome of the highly pathogenic avian influenza H5N1 virus: identification of human cellular regulators of viral entry, assembly, and egress
F Kien, HL Ma, R Bruzzone, LLM Poon, B Nal
HKU-Pasteur Research Pole, Hong Kong
Ksilink, French-German Advanced Translational Centre, Strasbourg, France
Centre of Influenza Research, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
1. Novel H5N1-human host protein-protein interactions were identified using a genome-wide yeast two-hybrid screen.
2. Annexin A6 interacts with the cytoplasmic tail of influenza A M2 protein.
3. Annexin A6 negatively regulates influenza A infection.
4. Annexin A6 impairs influenza A virus budding and release.