Screening of aqueous and organic extracts from a variety of fungi for their ability to antagonise the pathogenic yeast Candida albicans
JH Wong1, TB Ng1, M Hui2, RCF Cheung1, YS Chan1, X Dan1, HX Wang3
1 School of Biomedical Sciences, The Chinese University of Hong Kong
2 Department of Microbiology, The Chinese University of Hong Kong
3 State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China
1. Aqueous extracts and ethyl acetate extracts from the fruiting bodies and mycelia of various fungi were tested for anti-Candida albicans activity.
2. The aqueous extracts of the fruiting bodies of two mushrooms, Russula nigricans and Suillus placidus, elicited some inhibition of C albicans.
3. The ethyl acetate extracts of the fruiting bodies of all mushrooms did not produce a conspicuous inhibition of C albicans.
4. Accumulation of the nuclear dye SYTOX green in C albicans cells did not occur after exposure to the Russula nigricans and Suillus placidus aqueous extracts, suggesting that inhibition of C albicansis not due to a membrane permeabilising effect.