Hong Kong Med J 2015;21(Suppl 4):S22-6
Liver cirrhosis–specific glycoforms of serum proteins in chronic hepatitis B infection: identification by lectin affinity chromatography and quantitative proteomic profiling
TCW Poon, HLY Chan, HWC Leung, A Lo, RHY Lau, AY Hui, JJY Sung
Department of Medicine and Therapeutics, The Chinese University of Hong Kong
1. Carbohydrate side-chains of serum glycoproteins are altered in patients with liver cirrhosis.
2. Sialylated and fucosylated variants of serum glycoproteins are altered in chronic hepatitis B (CHB) patients with liver cirrhosis.
3. Particular sialylated Hp variants are down-regulated in CHB patients with liver cirrhosis, as are in patients having liver cirrhosis secondary to chronic hepatitis C, non-alcoholic fatty hepatitis or autoimmune hepatitis.
4. Development of novel practical assays that can quantify a specific glycosylated variant of a particular serum glycoprotein is needed.