Hong Kong Med J 2015;21(Suppl 4):S17-9
The role of cathelicidin in control of Helicobacter pylori colonisation in the stomach
CH Cho, J Yu, L Zhang, WKK Wu
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong
1. A new animal model for Helicobacter pylori infection in the stomach was established.
2. A probiotic was transformed with a host defence peptide cathelicidin. This preparation can be used for the treatment and prevention of H pylori infection and gastritis.
3. This oral biological preparation can also be used for the treatment of ulcerative colitis. It has multiple actions including anti-inflammatory, anti-bacterial, and maintenance of the defence mechanisms in the gastrointestinal mucosa.