Hong Kong Med J 2014;20(Suppl 6):S4-6
Use of humanised mice to study antiviral activity of human γδ-T cells against influenza A viruses
WW Tu, YL Lau, JSM Peiris
Department of Paediatrics and Adolescent Medicine, Department of Microbiology, The University of Hong Kong
1. Phosphoantigens could protect against influenza A (H1N1) virus infection in humanised mice with a human immune system.
2. This protection was strain-dependent for avian influenza A (H5N1) virus infection.
3. This suggests a novel therapeutic approach against influenza by using phosphoantigens to inhibit influenza A virus infection.
4. The humanised mouse model provides a low-cost platform for further studies of vaccines, stem cell biology, and therapeutics for human pathogens.