Hong Kong Med J 2013;19(Suppl 8):S31-3
Renal and vascular function in pregnant and neonatal rats exposed to melamine and related compounds
WT Wong, XY Tian, CW Lau, YX Wang, J Liu, WS Cheang, ZY Chen, CS Mok, CM Lau, Y Huang
Institute of Vascular Medicine, Li Ka Sing Institute of Health Sciences, School of Biomedical Sciences, The Chinese University of Hong Kong
1. In rats, long-term exposure to melamine impairs renal blood flow and renal vascular function in a dose-dependent manner.
2. Melamine-induced renal vascular dysfunction is caused by enhanced vasoconstriction and reduced vasodilatation owing to the endothelial cell dysfunction of renal arteries.
3. Endothelial dysfunction after melamine treatment is mediated through oxidative stress- dependent activation and up- regulation of cyclooxygenase 2, which produces prostanoids that act on the thromboxane receptor.
4. Transforming growth factor β1 and bone morphogenic protein 4 contribute to renal fibrosis induced by oral administration of melamine.
5. Exposure to melamine during pre- gnancy and lactation exaggerates renal vascular dysfunction in the offspring.