Hong Kong Med J 2013;19(Suppl 5):S15-8
Effect of IL-17 on enhancing innate immunity to mycobacterial infection
WL Ling, JW Fang, VLJ Wang, ASY Lau, JCB Li
Molecular Chinese Medicine Laboratory, LKS Faculty of Medicine, The University of Hong Kong
1. Interleukin (IL)-17A specifi- cally enhanced mycobacteria- induced IL-6 production in human macrophages.
2. IL-17A together with tumour necrosis factor-α could modulate mycobacteria-induced immune responses.
3. The nitric oxide production induced by mycobacteria could be further upregulated by IL- 17A.
4. IL-17A suppressed the survival of intracellular mycobacteria.