Hong Kong Med J 2013;19(Suppl 4):S6-10
Viral evolution from one generation of human influenza infection to the next
S Riley, BJ Cowling, KH Chan, JSM Peiris, GM Leung
School of Public Health, The University of Hong Kong
1. In a sub-tropical epidemic, most of the apparent household secondary cases are actually secondary infections.
2. The consensus sequence for the entire influenza virus genome is not usually identical within the same household sample. Rather, there are commonly one or two nucleotide changes.
3. These results hint at an obvious generational threshold for adaptation at the level of the consensus sequence.