Hong Kong Med J 2012;18(Suppl 6):S37-40
Association of polymorphism of human leukocyte antigen alleles with development of hepatocellular carcinoma in Hong Kong Chinese
MHL Ng, SH Cheng,PBS Lai, KKF Ling, KM Lau, CK Cheng, N Wong, BCY Zee, CK Lin
Department of Anatomical & Cellular Pathology, The Chinese University of Hong Kong, Hong Kong
1. Class I and II genes on homogenous cohorts of normal population controls, healthy hepatitis B virus (HBV) carriers, and HBV-positive hepatocellular carcinoma (HCC) patients were systematically studied using high-resolution human leukocyte antigen typing.
2. Human leukocyte antigen alleles DRB3*0201 and DQB1*050201 were positively and negatively associated with HCC development among carriers, respectively. The former allele was also confirmed to be independent of the HBV genotype.
3. These findings may help stratify the risks among HBV carriers for developing HCC and among the normal population for developing carrier status, thereby enabling more refined surveillance and planning and more cost-effective health resource allocation.