Hong Kong Med J 2012;18:412–8 | Number 5, October 2012
Stereotactic ablative radiotherapy for medically inoperable early stage lung cancer: early outcomes
Oscar SH Chan, Rebecca MW Yeung, Albert WM Hung, Michael CH Lee, Amy TY Chang, Connie CC Chan, Anne WM Lee
Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
OBJECTIVE. To evaluate the clinical outcome and safety of stereotactic ablative radiotherapy for medically inoperable stage I non- small-cell lung carcinoma.
DESIGN. Retrospective case series.
SETTING. Pamela Youde Nethersole Eastern Hospital, Hong Kong.
PATIENTS. All patients with medically inoperable stage I non-small-cell lung carcinoma receiving stereotactic ablative radiotherapy since its establishment in 2008.
MAIN OUTCOME MEASURES. Disease control rate, overall survival, and treatment toxicities.
RESULTS. Sixteen stage I non-small-cell lung carcinoma patients underwent the procedure from June 2008 to November 2011. The median patient age was 82 years and the majority (81%) had moderate-to-severe co-morbidity based on the Adult Comorbidity Evaluation 27 index. With a median follow-up of 22 months, the 2-year primary tumour control rate, disease-free survival and overall survival rates were 91%, 71% and 87%, respectively. No grade 3 (National Cancer Institute Common Terminology Criteria for Adverse Events) or higher treatment-related complications were reported
CONCLUSION. Stereotactic ablative radiotherapy can achieve a high degree of local control safely in medically inoperable patients with early lung cancer.
Key words: Carcinoma, non-small-cell lung; Lung neoplasms; Radiotherapy; Stereotaxic techniques; Survival rate
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