Hong Kong Med J 2012;18(Suppl 3):S20-3
Neuroprotection in steroid therapy: a rodent model
KF So, SW Tang, TMC Lee
Department of Anatomy, The University of Hong Kong, Hong Kong
1. Chronic steroid therapy causes disturbance in cell proliferation of the hippocampus and the subventricular zone. This may be the underlying cause of altered memory and cognitive function.
2. Co-administration of paroxetine (a class of antidepressants) during steroid therapy could counteract the destruction. Modification of the current steroid therapy regimen may be required.