Hong Kong Med J 2011;17(Suppl 6):S44-7
Hepatitis B virus X gene in the development of hepatocellular carcinoma
NF Ma, SH Lau, L Hu, SS Dong, XY Guan
Department of Clinical Oncology, The University of Hong Kong, Hong Kong
1. Deletion of the 3’end of the hepatitis B virus X gene (HBx) was frequently detected in clinical hepatocellular carcinoma (HCC) samples.
2. In vivo animal tumour xenograft experiments demonstrated the tumourigenic ability of the C-terminal truncated HBx.
3. cDNA microarray study suggested that the C-terminal truncated HBx played a critical role in the HCC development via activation of cell proliferation and inhibition of apoptosis.