Hong Kong Med J 2011;17(Suppl 6):S26-30
Identification of T-cell epitopes of SARS-coronavirus for development of peptide-based vaccines and cellular immunity assessment methods
PKS Chan, S Ma, SM Ngai
Department of Microbiology, The Chinese University of Hong Kong, Hong Kong
1. Subjects recovered from SARS-CoV infection retain memory of cellular immune response to epitopes spanning over a few regions of the viral nucleoprotein. Ten such epitopes were identified.
2. The majority of epitopes were predominantly recognised by CD8+ cytotoxic T cells and elicited persistent memory response lasting at least 2 years.
3. There is potential to use the nucleoprotein of SARS-CoV to develop vaccines and diagnostic assays based on such cellular immune responses.