Hong Kong Med J 2011;17(Suppl 6):S22-5
Tuberculosis susceptibility genes in the chemokine cluster region of chromosome 17 in Hong Kong Chinese
NLS Tang, CY Chan, CC Leung, CM Tam, J Blackwell
Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
1. There was a borderline association between a single nucleotide polymorphism (SNP) located within the CCL1 gene and predisposition to tuberculosis using a single-point analysis. The association was no longer significant when the effect of multiple statistical testing was taken into account.
2. This SNP was also associated with tuberculosis diagnosed in young patients (<35 years old).
3. This SNP was not associated with other clinical features such as smear positivity and extent of disease.