Hong Kong Med J 2011;17(Suppl 2):S29-31
Methionine aminopeptidase as a novel target for antibiotic therapy against Staphylococcus aureus: a proteomic approach
RYT Kao, KY Yuen, CM Che, FM Siu
Department of Microbiology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong
1. Methionine aminopeptidase (MetAP) is an essential enzyme in Staphylococcus aureus and a potential target for novel antibiotics.
2. Two-dimensional electrophoresis gel identified more than 100 differences in protein expression between wild type and MetAP-deficient strains of S aureus.
3. Using mass spectroscopic techniques, 63 differentially expressed proteins were identified, of which some were related to purine biosynthesis and methionine metabolism.