Hong Kong Med J 2010;16:186–91 | Number 3, June 2010
Surgical management of primary non-small-cell carcinoma of lung with synchronous solitary brain metastasis: local experience
CK Lo, CH Yu, CC Ma, KM Ko, Samuel CL Leung
Department of Cardiothoracic Surgery, Queen Elizabeth Hospital, Kowloon, Hong Kong
OBJECTIVE. To report the surgical experience in the management of patients with synchronous primary lung cancer and solitary brain metastasis.
DESIGN. Retrospective cohort study.
SETTING. Regional hospital, Hong Kong.
PATIENTS. Seventeen patients with synchronous primary lung cancer and solitary brain metastasis were treated by pulmonary resection and neurosurgical intervention between 1994 and 2007.
RESULTS. Median patient survival was 52 months (95% confidence interval, 9-95 months) and the 5-year survival was 27%. The univariate analysis yielded no significant prognostic factor. Four out of six patients who had lymph node metastases developed tumour recurrence.
CONCLUSION. In view of encouraging survival results, aggressive therapy including pulmonary resection and neurosurgical intervention should be recommended for patients with synchronous presentation with primary lung cancer and solitary brain metastasis.
Key words: Brain neoplasms; Carcinoma, non-smallcell lung; Lung neoplasms; Survival rate
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