Hong Kong Med J 2009;15(Suppl 8):S42-4
Serum total glycosylation profiling for non-invasive diagnosis of liver cirrhosis in people with chronic hepatitis B
TCW Poon, RKT Kam, JJY Sung, N Wong, AY Hui, HLY Chan
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
1. A high-throughput assay for quantitative profiling of N-glycans attached to serum glycoproteins has been established.
2. A panel of serum N-glycans were identified as potential biomarkers for diagnosing liver cirrhosis and liver fibrosis.
3. Four glycan peaks of 1341.5, 1829.7, 1933.3, and 2130.3 m/z were all able to detect liver fibrosis and cirrhosis with 85% accuracy.