Hong Kong Med J 2009;15(Suppl 6):S26-9
Functional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection
US Khoo, KY Chan, JCY Ching, VS Chan, YC Ip, L Yam, CM Chu, ST Lai, KM So, TY Wong, PH Chung, P Tam, SP Yip, P Sham, GM Leung, CL Lin, JSM Peiris
Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
1. Severe acute respiratory syndrome (SARS) patients who are homozygous for intercellular adhesion molecule-3 (ICAM-3) Gly143 showed significant association with higher lactate dehydrogenase levels and lower total white blood cell counts on admission.
2. In vitro functional studies demonstrated low level binding of ICAM-3 to DC-SIGN and a wide variation in T-cell response of the wild-type ICAM-3 genotype.