Hong Kong Med J 2009;15:221-3 | Number 3, June 2009
Fibromatosis of the neck causing airway obstruction managed effectively with weekly low-dose methotrexate and vinblastine
Henry Sze, MW Yeung
Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
Fibromatosis is a rare disease with benign histology. Its infiltrative growth pattern may prevent complete resection. We report a case of a 40-year-old woman with fibromatosis of the neck requiring an emergency operation for acute upper airway obstruction. Gross residual tumour was left behind but excellent tumour shrinkage was achieved by using weekly low-dose methotrexate and vinblastine. Despite the use of newer agents such as imatinib, cytotoxic chemotherapy remains an efficacious treatment for inoperable fibromatosis.
Key words: Airway obstruction; Chemotherapy, adjuvant; Fibromatosis, aggressive; Head and neck neoplasms
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