Hong Kong Med J 2009;15(Suppl 4):S32-6
Immunotherapy of mycobacterial infections: a cell and molecular model
BKW Cheung, MMP Chan, HCH Yim, LL Chan, JCB Li, DCW Lee, ASY Lau
Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong
1. RNA-activated protein kinase serves as an important molecule in an innate defence against mycobacteria.
2. Exogenous interferon-_ can reverse the immunosuppressive role of interleukin-10 prevailing in the presence of mycobacterial infection.
3. This study provides new therapeutic strategies for the global tuberculosis pandemic, in particular for AIDS patients with multidrug-resistant mycobacteria.