Hong Kong Med J 2008;14(Suppl 4):S8-13
SARS coronavirus and apoptosis
KY Chow, YS Yeung, CC Hon, F Zeng, KM Law, FC Leung
1. The adenovirus-mediated overexpression of SARS coronavirus (SARS-CoV) spike protein (S) and its C-terminal domain (S2) induce apoptosis in Vero E6 cells.
2. Such apoptosis in Vero E6 cells is time- and dose-dependent.
3. The adenovirus-mediated overexpression of SARS-CoV N-terminal domain (S1) and other structural proteins, including E,M and N protein, do not induce apoptosis.
2. Such apoptosis in Vero E6 cells is time- and dose-dependent.
3. The adenovirus-mediated overexpression of SARS-CoV N-terminal domain (S1) and other structural proteins, including E,M and N protein, do not induce apoptosis.