Hong Kong Med J 2008;14(Suppl 1):S17-20
Avascular necrosis of bone in patients with graft-versus-host disease after allogeneic haematopoietic stem cell transplantation and corticosteroid therapy: a magnetic resonance imaging study
YL Kwong, Y Wong, KW Lie
Department of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
1. Magnetic resonance imaging evidence of osteonecrosis occurs in about one third of patients who had received corticosteroid therapy for graft-versus-host disease after haematopoietic stem cell transplantation.
2. The only risk factor identified in this cohort of patients that predisposed to osteonecrosis was transplantation for acute lymphoblastic leukaemia.
3. The cumulative dose of corticosteroids was unrelated to the occurrence of osteonecrosis.
4. Patients with osteonecrosis were comparable to patients without osteonecrosis in symptomatology.