Molecular stratification of gliomas using next-generation sequencing: abridged secondary publication
AKY Chan, DTM Chan, JYT Chan, H Chen, NYF Chung, QJQ Huang, JSH Kwan, KKW Li, WC Li, EM Liu, XZ Liu, HHF Loong, TM Malta, Y Mao, HK Ng, H Noushmehr, MFM Poon, WS Poon, ZF Shi, WW Wang, ZY Zhang
Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
- Adult diffuse gliomas are heterogeneous groups of tumours.
- A combination of single-gene biomarkers can be used to stratify adult gliomas into molecular groups. Our proposed molecular grading system is superior to the histological grading system in terms of prognostication for adult gliomas.
- IDH-wildtype, TERTp-wildtype adult glioblastomas clustered into different methylation classes, and CDKN2A/B deletion is an independent prognostic factor in this subset of gliomas.
- Methylation classes, MGMTp methylation, TERTp mutation, and MMR mutation are prognostic biomarkers for IDH-wildtype, H3-wildtype glioblastomas in adolescents and young adults. These tumours are similar to the above IDH-wildtype, TERTp-wildtype glioblastomas in that they do not frequently exhibit the diagnostic molecular criteria for regular glioblastomas.