Hong Kong Med J 2025;31(Suppl 4):S22-3
Whole genome stability of SARS-CoV-2: abridged secondary publication
MH Wang1, MKC Chong1, ELY Wong1, PKS Chan2, Z Chen2, CKC Lai3, RCW Chan3
1 JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China
2 Department of Microbiology, The Chinese University of Hong Kong, Hong Kong SAR, China
3 Department of Health, Hong Kong SAR, China
 
 
  1. Understanding virus evolution is important for pandemic preparedness and response. Characterisation of genome stability of SARS-CoV-2 enables evaluation of the virus’s evolutionary rate and the potential risk of COVID-19 vaccine breakthrough.
  2. The receptor-binding domain region of the spike protein was associated with a significant risk of COVID-19 vaccine breakthrough.