Tuen Mun hospital followed up 72 patients of atypical glandular
cells of undetermined significance (AGUS) for 2 years, and revealed
that more than 20% of such patients had premaglinant or malignant
disease during the period. The research results are published
in the new issue Hong Kong Medical Journal.
From 1998 to 1999, 21 854 Papanicolaou smear samples were evaluated
at Tuen Mun Hospital, and 83 (0.4%) of them were interpreted
as containing AGUS. Among the 72 patients who attended followed
up, 43% had significant diseases of the genital tract. Follow-up
for 2 years revealed that the incidence of significant disease,
such as adenocarcinoma of cervix and endometrial carcinoma,
ranged from 8% (AGUS-favour reactive) to 90% (AGUS-favour neoplasia).
Researchers pointed out that the histological outcome of AGUS
was so broad that they included benign and neoplastic changes
of both squamous and glandular cell from the cervix, uterus,
or even other parts of the body. AGUS patients should undergo
early thorough investigation of the cause, because many of them
will have premalignant or malignant disease.