Hong Kong Med J 2012;18:395–406 | Number 5, October 2012
The CEPHEUS Pan-Asian survey: high low-density lipoprotein cholesterol goal attainment rate among hypercholesterolaemic patients undergoing lipid-lowering treatment in a Hong Kong regional centre
Raymond HW Chan, PH Chan, Kelvin KW Chan, Simon CC Lam, Jo Jo Hai, Michael KL Wong, Frankie CC Tam, Linda Lam, Carmen WS Chan, YM Lam, David CW Siu, HF Tse, Stephen WL Lee
Division of Cardiology, Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong
OBJECTIVES. To evaluate attainment of low-density lipoprotein cholesterol goals among hypercholesterolaemic patients undergoing lipid-lowering drug treatment in Hong Kong and to identify potential determinants of treatment outcomes.
DESIGN. Cross-sectional observational study.
SETTING. A single site in Hong Kong, as part of the CEPHEUS Pan-Asian survey.
PATIENTS. Subjects with hypercholesterolaemia aged 18 years or above, who had been on lipid-lowering drug treatment for at least 3 months with no dose adjustment for at least 6 weeks.
RESULTS. A total of 561 such patients (mean age, 65.3; standard deviation, 9.7 years) were evaluated. Most had major cardiovascular risk factors; 534 (95.2%) of 561 patients had coronary heart disease and 534 (95.4%) of 560 patients had low-density lipoprotein cholesterol goals set at lower than 70 mg/dL. In all, 465 (82.9%) patients attained their respective low-density lipoprotein cholesterol goals. Among 75 patients who had coronary heart disease or equivalent risk, and multiple risk factors with a 10-year coronary heart disease risk of over 20%, 62 (82.7%) attained their respective low-density lipoprotein cholesterol goals. Significant predictors of low-density lipoprotein cholesterol goal attainment included the patient's baseline lipid profile (total cholesterol and low-density lipoprotein cholesterol levels), blood pressure, and drugs (statin/non-statin) used for treatment.
CONCLUSIONS. Hypercholesterolaemic patients undergoing lipid-lowering drug treatment in the present Hong Kong study were able to achieve a very high attainment rate for the low-density lipoprotein cholesterol goal, despite the fact that most of them had major cardiovascular risk factors.
Key words: Anticholesteremic agents; Cardiovascular diseases/prevention & control; Cholesterol, LDL; Hypercholesterolemia; Treatment outcome
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