Hong Kong Med J 2010;16:400-2 | Number 5, October 2010
Adult hepatic cavernous haemangioma with highly elevated alpha-fetoprotein
SL Han, XL Wu, ZR Jia, PF Wang
Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou City 325000, Zhejiang Province, PR China
A 35-year-old Chinese man presented with dull pain in the right hypochondrial region for the previous 2 months. Laboratory examination revealed that his serum alpha-fetoprotein level was 1890 ug/L (reference range, 0-20 ug/L), and computed tomographic scan showed a hypodense lesion in the left liver lobe. At laparotomy, a dark reddish soft tumour (3.0 x 3.5 cm in diameter) was found in the medial segment of the liver (segment III). The tumour became markedly smaller than that before resection, and a vessel-like structure was found on the cut surface. Intra-operative pathology and postoperative histopathology examinations revealed that the tumour was a cavernous haemangioma of the liver. The serum alpha-fetoprotein level decreased to 3.5 ug/L by the fourth postoperative week. Clinicians should be aware that some rare tumours besides hepatocellular carcinoma and endodermal sinus tumours (yolk sac tumour), for example, hepatic haemangioma, can produce alpha-fetoprotein.
Key words: alpha-Fetoproteins; Carcinoma, hepatocellular; Hemangioma; Liver neoplasms
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