Hong Kong Med J 2010;16(Suppl 4):S22-6
The role of SARS-CoV protein, ORF-6, in the induction of host cell death
ZD Ye, CK Wong, P Li, Y Xie
Department of Biology, Hong Kong University of Science and Technology, Hong Kong
 
 
1. Overexpression of ORF-6 induced apoptosis.
2. Caspase-3 inhibitor and JNK inhibitor blocked ORF-6 induced apoptosis.
3. The protein level of ER chaperon protein, GRP94, was up-regulated when ORF-6 was overexpressed.
4. ORF-6 induced apoptosis via caspase-3–mediated, ER stress and JNK dependent pathways.