Hong Kong Med J 2009;15(Suppl 8):S15-8
Proteomic profiling in SARS: diagnostic and prognostic applications
TCW Poon, RTK Pang, KCA Chan, NLS Lee, RWK Chiu, YK Tong, SSC Chim, SM Ngai, JJY Sung, YMD Lo
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
1. Disease-specific proteomic fingerprints were found in SARS patients.
2. The two proteomic features yielding the largest receiver operating characteristic curve area (diagnostic accuracy of >95%) were an N-terminal fragment of complement C3c _-chain (m/z 28119) and an internal fragment of fibrinogen alpha-E chain (m/z 5908).
3. In contrast to previous proteomic studies, we found that serum amyloid A was not useful in the diagnosis of SARS.
4. The potential prognostic features of m/z 7768 and m/z 8865 were found to be platelet factor 4 and beta-thromboglobulin, respectively.
2. The two proteomic features yielding the largest receiver operating characteristic curve area (diagnostic accuracy of >95%) were an N-terminal fragment of complement C3c _-chain (m/z 28119) and an internal fragment of fibrinogen alpha-E chain (m/z 5908).
3. In contrast to previous proteomic studies, we found that serum amyloid A was not useful in the diagnosis of SARS.
4. The potential prognostic features of m/z 7768 and m/z 8865 were found to be platelet factor 4 and beta-thromboglobulin, respectively.