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Oncogenic osteomalacia associated with an occult
phosphaturic mesenchymal tumour: clinico-radiologico-pathological
correlation and ultrastructural studies
FMF Cheung, L Ma, WC Wu, TH Siu, PT Choi,
YP Tai
Department of Pathology, Pamela Youde Nethersole Eastern
Hospital, Chai Wan, Hong Kong
A middle-aged man presented with bone pain at multiple sites
due to tumour-induced osteomalacia. The underlying occult phosphaturic
mesenchymal tumour was identified by octreotide scan 5 years after
presentation and confirmed by computed tomography. Tumour resection
resulted in normalisation of blood chemistry and bone densitometry.
Clinico-radiologico-pathological correlation and ultrastructural
studies of the tumour threw light on the pathogenesis and pathophysiology
of this rare disease.
Hong Kong Med J 2006;12:319-21
Key words: Fibroblast growth factors; Osteomalacia;
Soft tissue neoplasms
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