Hong Kong Med J 2005;11:259-66 | Number 4, August 2005
Idiopathic macular hole surgery in Chinese patients: a randomised study to compare indocyanine green–assisted internal limiting membrane peeling with no internal limiting membrane peeling
AKH Kwok, TYY Lai, VWY Wong
Department of Ophthalmology, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong
OBJECTIVE. To compare the anatomical and visual outcomes of primary idiopathic macular hole surgery using indocyanine green–assisted internal limiting membrane peeling versus no internal limiting membrane peeling.
DESIGN. Prospective randomised controlled clinical trial.
SETTING. University teaching hospital, Hong Kong.
PATIENTS. Fifty-one eyes of 49 Chinese patients with primary idiopathic macular hole were studied.
INTERVENTIONS. Patients were randomised to undergo pars plana vitrectomy with indocyanine green–assisted internal limiting membrane peeling (26 eyes) or surgery without internal limiting membrane peeling (25 eyes). Perfluorocarbon gas was used in all cases as internal tamponade.
MAIN OUTCOME MEASURES. Primary macular hole closure rate and best-corrected visual acuity.
RESULTS. The mean follow-up duration was 12 months (range, 6-23 months). Respectively to the indocyanine green–assisted internal limiting membrane peeling group and non–internal limiting membrane peeling group, the primary anatomical closure rate was 92.3% and 32.0% (P
CONCLUSION. Indocyanine green–assisted internal limiting membrane peeling in idiopathic macular hole surgery results in significantly better anatomical and visual outcomes compared with non–internal limiting membrane peeling in Chinese patients.
Key words: Basement membrane; Epiretinal membrane; Indocyanine green; Retinal perforations; Vitrectomy
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